A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocontainers.

Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles.

A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.

Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles.

Enzyme and voltage stimuli are more biologically compatible in the field of stimuli-responsive systems and release systems based on β-cyclodextrin (CD) and ferrocene (Fc) have attracted much attention. Herein, mesoporous silica nanoparticles (MSNs) have been functionalized with the ferrocenyl moiety (Fc) which interacts with β-cyclodextrin (β-CD) to form an inclusion complex on the opening of t...

Bioresponsive Controlled Release of Cargo with Glucometer Readout from Mesoporous Silica Nanocontainers for Sensing Non-Glucose Targets

Peptide modified mesoporous silica nanocontainers.

Here we report a new peptide modified mesoporous silica nanocontainer (PMSN) as a novel controlled release system. The peptides are part of a stimuli responsive nanovalve and ensure an efficient cellular uptake.

A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles.

A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.